Course catalogue doctoral education - HT17

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Title Omics data analysis: From quantitative data to biological information
Course number 2523
Program 1-Ingår i flera program
Language English
Credits 3.0
Date 2017-11-06 -- 2017-11-17
Responsible KI department Institutionen för onkologi-patologi
Specific entry requirements
Purpose of the course During recent years omics data has become an integral part of many current biomedical and clinical research projects. This course aims at bridging the gap between bioinformatics and classical biomedical research. The course will give students an introduction to omics technologies and basic knowledge of omics data analysis workflows.
Learning outcomes After completed course, the student will be able to:
* Understand the principles and perform the basics of high-throughtput technologies and the omics data analysis workflow (genomics, transcriptomics, proteomics,)
* Understand the principles aspects of study design, experimental planning and sample selection
* Know how to do basic quality control of data by use of boxplots, PCA etc
* Know what normalization, data transformation etc means and what it does to your data
* Know the principles of some basic statistics such as t-test and false discovery rate
* Know the principles of dimensionality reduction methods such as PCA and tSNE
* Use tools for hierarchical clustering, functional enrichment and pathway analysis
* Use tools for gene ontology (GO) annotation/enrichment
Contents of the course * The omics data analysis workflow: from quantitative data to biological information (emphasis on analysis of genomics, transcriptomics, and proteomics data) * Introduction to omics technologies and data structures * Omics experimental design and sample selection * Introduction to data transformation and normalisation * Introduction to basic statistics in omics data analysis: significance test/p-values/multiple testing correction/false discovery rate * Introduction to dimensionality reduction PCA/MDS/tSNE * Introduction to Gene Ontology and enrichment analysis * Introduction to correlation analysis and hierarchical clustering * Introduction to network and pathway analysis * Introduction to online bioinformatics resources and analysis tools * Introduction to the R statistical programming language * Literature study with a critical view on how omics data is analyzed in clinical research. * Current state of the art in omics data analysis is highlighted through case studies, literature studies and demonstrations
Teaching and learning activities The teaching activities for the course will be based on lectures, workshops and data analysis cases. The students will participate in a literature study with discussions in seminar groups as well as an independent data analysis exam project. The students will also be able to download and use some of the software in workshops during the course.
Compulsory elements * Attendance on lectures and data analysis demonstrations. * Attendance to literature study discussion seminar. * Attendance to examination seminar and hand in the written examination assignments. * Extra written literature study can be used to compensate absence.
Examination The course assessment is based on two type of assignments: a literature study with a critical view on an omics data analysis subject performed in groups and an individual written omics data analysis project illustrating the different topics covered during the course.
Literature and other teaching material Literature will consist of recent original and review articles and will be provided to students as PDF files.
Number of students 15 - 25
Selection of students Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date)
More information Lectures will be given at Widerströmska huset, Tomtebodavägen 18a, Solna and at SciLifeLab, Tomtebodavägen 23a, Solna. Schedule and additional information will be uploaded at the course web site closer to course start. Course website: https://pingpong.ki.se/public/courseId/12933/lang-sv/publicPage.do?item=11900121
The course is jointly organized by the doctoral programmes Allergy, immunology and inflammation (Aii), Biology of Infections and Global Health (BIGH), Development and Regeneration (DevReg) and Tumor biology and oncology (FoTO). See: https://internwebben.ki.se/en/doctoral-programmes-0.
Course directors
Earlier evaluation of the course Evaluation report
Course responsible Lukas Orre
Institutionen för onkologi-patologi

Lukas.Orre@ki.se
Contact person Erik Fredlund
Institutionen för onkologi-patologi
0709395652
erik.fredlund@ki.se

Scilifelab, Alfa1, Proteomics, Tomtebodavägen 23A

17165
Stockholm