Course catalogue doctoral education - VT18

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Title Basic immunology
Course number 2302
Program Allergi, immunologi och inflammation (Aii)
Language English
Credits 3.0
Date 2017-09-26 -- 2017-10-26
Responsible KI department Institutionen för medicin, Solna
Specific entry requirements
Purpose of the course The purpose is to give doctoral students lacking a solid knowledge and understanding of fundamental principles in immunology the possibility to obtain this through a high quality basic course. All other courses in the Doctoral education programme Aii (Allergy, immunology and inflammation) assume that students have taken the Basic Immunology course, or otherwise have attained the same level of previous knowledge and understanding.
Learning outcomes To understand basic principles of innate and adaptive immunity and how different components of the immune system cooperate.
To be able to relate, compare and understand experimental aspects of immune-related disease in a clinical perspective.
To adapt knowledge gained of the function of the immune system by being able to analyze and discuss an immunological/clinical case (group project).
To present the group project and discuss the results as well as work in pairs with clinical cases.
Contents of the course The course is separated into two parts. In part 1 we discuss basic immunological mechanisms within the innate and adaptive immune response. In part 2 we apply the knowledge in clinical settings such as defence against infection, autoimmune and allergic disease or transplantation. Part 1: Introduction An overview of the immune system T cells B cells Antigen-presenting cells Innate vs adaptive immune responses Part 2: Immune defence against bacterial and viral infections Primary immunodeficiencies Autoimmune disease Allergy Vaccination Clinical Immunology Transplantation Tumour Immunology Questions and discussions Presentation of projects.
Teaching and learning activities The course is given full-time during a total of six days separated into two parts. The teaching is mainly in lecture/seminar form but also includes project work in small groups, as well as a written assignment. The group projects are then presented orally on the last day of the course. The project work and written assignment require studies between the two course parts, including meetings with mentors. Course literature (Abbas) is handed out at the course start. An immunological quiz is connected to the different chapters in the book so that the student will be able to digest the relatively big material. The course is designed so that clinically active doctors will be better able to combine it with work in the clinic (Mondays and Fridays contain no scheduled course work) .The purpose of dividing the course into two parts is that the participants should have time to thoroughly study the literature from part 1 (fundamental immunological mechanisms) before teaching of the applied immunology in part 2 starts. Considering the substantial literature requirement plus the written assignment and project work, we estimate that an extra 32h of study is needed, which is not included in the schedule.
Compulsory elements Discussion sessions, group project work and participation at the project presentation is compulsory as well as work with the written assignment. In the case of absence a separate occasion is organized with presentation for the course organizers.
Examination Evaluation by the group project mentor and oral presentations of small-group project work. At this occasion special attention is given to that all students are actively participating. The written assignment is evaluated by the course organizers and - with respect to proposing new research ideas related to the students´own PhD projects - by their supervisors.
Literature and other teaching material Abul Abbas and Andrew Lichtman: Basic Immunology. (Saunders Elsevier). The book is free and is handed out at the course start. Lecture handouts uploaded to the course website. Scientific review articles proposed by group project mentors.
Number of students 12 - 50
Selection of students Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date)
More information The course is divided into two sessions with 3 days of lectures each, September 26-28 and Oktober 24-26 (Tuesday to Thursday). In between these days of lectures the students work on both a group project and an individual written assignment, including meetings with mentors and literature studies. Teachers include specialists in different fields of immunology including both basic and clinical researchers. We will use the Abbas "Basic Immunology" as the main course textbook, but literature also includes review papers, handouts etc. The texbook the book is free and is handed out at the course start. The course location is at the Center for Molecular Medicine (CMM), Karolinska University Hospital, Solna
Additional course leader The course is also given in the spring, by Lisa Westerberg and Mikael Karlsson (MTC)
Earlier evaluation of the course Evaluation report
Course responsible Johan Öckinger
Institutionen för medicin, Solna
0851770663
Johan.Ockinger@ki.se
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