Course catalogue doctoral education - HT17

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Title Tumor microenvironment
Course number 2671
Program Tumörbiologi och onkologi (FoTO)
Language English
Credits 1.5
Date 2017-10-02 -- 2017-10-06
Responsible KI department Institutionen för onkologi-patologi
Specific entry requirements Basic course in tumor biology and oncology or corresponding knowledge.
Purpose of the course The course will provide the students with a basic knowledge within the relatively new field of tumor microenvironment by describing the interaction between tumor cells and tumor associated cells including the extracellular matrix. The students will be enabled to develop understanding of pros and cons with in vitro co-culturing and in vivo tumor models.
Learning outcomes After completion of the course, the students will be able to describe and discuss tumor microenvironment with tumor associated cells, inflammatory processes and hypoxia/angiogenesis and how they contribute to the carcinogenic process. Students will also be able to describe which tumor associated cells are known to affect the tumor progression and, in some cases, the tumor initiation. The students will develop understanding of pros and cons with in vitro coculturing and in vivo tumor models. Clinical applications within the field are presented during the course.
Contents of the course The course is designed for PhD students with an interest in tumor biology. The course will specifically address the concepts of cancer associated fibroblasts and macrophages, hypoxia, tumor metabolism, metastasis and tumor vascular angiogenesis and lymphangiogenesis. Clinical applications within the field are presented during the course.
Teaching and learning activities The course is designed for PhD students with an interest and personal involvement in tumor biology. It consists of lectures and group discussions based on problem based learning on topics related to the course, with the specific aim to stimulate an active participation from the course participants together with course lecturers. Students are expected to discuss the developments of the TME field and present their views on the central issues of pre-clinical versus clinical use of anti-TME therapies.
Compulsory elements Attendance to all the activities of the course and the written examination are mandatory. Absence from mandatory parts of the course will have to be compensated for by other activities after discussion with the course leaders.
Examination The course assignment will consist of an oral discussion of a problem-based case and the assessment will be performed on an individual basis. One or two students will be appointed as reviewer(s) to provide peer feedback for the presenter, in line with concept of formative assignment. The course organizers will lead the examination and be responsible for summative individual assessment.
Literature and other teaching material Selection of recommended recently published research papers on the topic.
Number of students 15 - 25
Selection of students Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date)
More information The course will be held at CCK lecture Hall, R8:00, Karolinska University Hospital, Solna.
Course directors
Earlier evaluation of the course Evaluation report
Course responsible Rainer Tuominen
Institutionen för onkologi-patologi

Rainer.Tuominen@ki.se
Contact person Suzanne Egyhazi Brage
Institutionen för onkologi-patologi

Suzanne.Egyhazi.Brage@ki.se