Kurskatalog forskarutbildning - VT18

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Titel Mouse models of human cancer
Kursnummer 2367
Program Tumörbiologi och onkologi (FoTO)
Språk Engelska
Antal högskolepoäng 1.5
Datum 2017-11-27 -- 2017-12-04
Kursansvarig institution Institutionen för klinisk vetenskap, intervention och teknik
Särskild behörighet Knowledge of the concept of the gene, i.e. knowledge about regulatory sequences such as promoter/enhancer, intron, exon as well as DNA replication, transcription and translation are essential to understanding the course content and is therefore a prerequisite for participation in the course.
Kursens syfte The aim of the course is to convey an enhanced knowledge about the generation and use of mouse
models in cancer research, as well as to empower the student to make an informed decision of suitable
models for his/her own research situation.
Kursens lärandemål After completion of the course, the student should be able to:
- Compare and contrast different categories of mouse models of cancer and analyze the pros and cons of models within each category
- Apply state-of-the-art technology in the generation and use of mouse models of cancer
- Relate the knowledge about mouse models of cancer to his/her own research
- Independently be able to search for more information about mouse models of cancer
Kursens innehåll The course will provide an introduction to the generation of mouse models of human cancer using transgene technology, homologous recombination as well as gene editing (CRISPR/Cas9) . A survey of the state-of-the-art technologies in the field, such as conditionality, inducibility, lineage tracing and multimodal life-imaging including a visit and live-demonstration in the imaging facility of the animal house will be provided. An expert mouse pathologist will give an eye-opener on what is possibly not related to a genetically engineered phenotype but other disease conditions of the mouse. Also, the use of mouse models in various applications related to cancer research, such as studies of metastasis or experimental therapy/preclinical testing, will be reviewed. Mouse models of particular interest will be highlighted. In parallel, literature studies of mouse models of specific indications will be performed by the students, with the aim of designing new and improved mouse models.
Arbetsformer 1. Lectures will provide knowledge about the current state of the field. 2. Case in point seminars will highlight mouse models of cancer of particular importance. 3. Group assignments will be used to perform a literature review and gain insight into disease-specific mouse models of cancer.
Obligatoriska moment Attendance is compulsory during all lectures and scheduled time slots for the group assignment. Absence has to be compensated for in accordance with the course organizer.
Examination Course examination is composed of two parts: 1. Oral exam, consisting of a powerpoint presentation and discussion of the group assignments, in which the students will present the design of a new and improved mouse model of human cancer. 2. Handing in of powerpoint presentation with corrections based on oral exam.
Kurslitteratur och övriga läromedel The selection of literature is made in such a way as to aid the student in fulfilling the learning outcomes of the course. Literature in the form of current review articles on relevant topics, as well as original research papers describing illustrative examples of the use of mouse models of cancer will be provided during the course.
Antal studenter 8 - 16
Urval av studenter Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date)
Övrig information Lectures will be held November 27 to November 30. The exam will take place on December 4. Venue: Huddinge, KI South Campus, room to be announced.
Ytterligare kursledare
Tidigare omdöme av kursen omdöme
Kursansvarig Rainer Heuchel
Institutionen för klinisk vetenskap, intervention och teknik
08 585 830 33
rainer.heuchel@ki.se
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