Course catalogue doctoral education - HT17

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Title Autophagy, metabolism and cancer
Course number 2898
Program Tumörbiologi och onkologi (FoTO)
Language English
Credits 1.5
Date 2017-11-06 -- 2017-11-10
Responsible KI department Institutionen för fysiologi och farmakologi
Specific entry requirements General prior knowledge in cell biology
Purpose of the course The main purpose of this course is to enable deep understanding of the main principles of the process of autophagy and metabolic pathways as well as their regulation in cancer. Furthermore, students should reach an advanced level in the fields of autophagy and metabolism as the course syllabus has prominent educational significance for the doctoral student that covers these two broad scientific fields, which can be applied both for basic and clinical research.
Learning outcomes After completion of the course the students should be able to demonstrate broad knowledge and a systematic understanding of the fundamental processes of autophagy and metabolism as well as in-depth and up-to-date knowledge of these pathways and their integrating in cancer survival and development.

In particular the course participants should be able to:

a) Describe the fundamental mechanisms of autophagy pathways and their regulation in cancers.

b) Describe the main metabolic pathways in normal and tumor conditions.

c) Explain the relation between autophagy and metabolism.

d) Describe the main methods to monitor autophagy and metabolism.

d) Apply the knowledge acquired during the course to create a theoretical research project proposal.
Contents of the course Fundamental aspects of cellular autophagy and metabolism and how these pathways are regulated in physiological and pathological conditions will be covered. Particular focus will be given to human cancers.
The following topics listed below will be overviewed:
Cellular and molecular mechanisms of different autophagic pathways, genetic and pharmacological modulation of autophagy, the role of autophagy in cancers; metabolic pathways, cancer cell metabolism, metabolic control of autophagy, current methods to assay autophagy and metabolism.
Teaching and learning activities The course will include a series of learning activities, such as introductory and comprehensive lectures/seminars, group work, student's presentations and general discussion.
Compulsory elements Attendance to all the activities of the course and the individual presentation of a research proposal are mandatory. Absence from mandatory parts of the course will be compensated by other activities after discussion with the course leaders.
Examination The course assignment will consist on an individual presentation of a research proposal, based on the course topics. One or two students will be appointed as reviewer(s) for each presentation to provide peer feedback for the presenter, in line with concept of formative assessment. The course organizers will describe the content and organization of the presentation and discussion during the introductory lecture on the starting of the course. The course organizers will lead the examination and be responsible for summative individual assessment.
Literature and other teaching material Recent and relevant journal articles distributed prior to the course.
Number of students 8 - 20
Selection of students Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date)
More information
Course directors erik.norberg@ki.se helin.norberg@ki.se
Earlier evaluation of the course Evaluation report
Course responsible Helin Norberg
Institutionen för fysiologi och farmakologi

helin.norberg@ki.se
Contact person Erik Norberg
Institutionen för fysiologi och farmakologi

erik.norberg@ki.se