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Title Vascular Cell Biology
Course number 1544
Programme Kardiovaskulär forskning
Language English
Credits 1.5
Date 2017-05-15 -- 2017-05-19
Responsible KI department Institutionen för molekylär medicin och kirurgi
Specific entry requirements _
Purpose of the course The main purpose of this course is to give doctoral students a basic understanding of the vascular wall, its components, functions and regulation.
Intended learning outcomes After a successfully completed course, the student should be able to
1) Account for the various cell types and extracellular matrix components in the vascular wall, 2) understand the interaction between the different cell types and matrix components and the effect by/on the systemic circulation and 3) be able to identify and understand the principles for both in vitro and in vivo methods used to study the vascular wall.
Contents of the course The course provides an introduction to and the methods used to study the basic cell types and extracellular matrix components present in the vascular wall, with special emphasis on smooth muscle cells and endothelial cells. Focus will also be put on the basic cell biological processes (activation, migration, proliferation, apoptosis) involved in the main vascular pathologies such as atherosclerosis, hypertension, diabetes and aneurysm development. Vascular development and remodelling (angiogenesis, arteriogenesis) will be discussed. Cell-cell and cell-matrix interaction and signaling will be addressed. We will also take into account the differences in function with regard to the arterial, venous and lymphatic systems.
Teaching and learning activities Lectures, project presentation, group seminars and study visit to a vascular laboratory.
Compulsory elements Group work and examination. If the student does not take part in the above, he/she will be asked to visit a vascular laboratory and submit a report. A written examination will be required for those students who do not attend the Course examination.
Examination The examination will consist of project presentation by the individual students, presentation from the visit to the vascular laboratory and discuss groupwise 2-3 questions that will be distributed to the students beforehand.
Literature and other teaching material 1. M. Piper, (Ed.), Cell Culture Techniques in Heart and Vessel Research, Springer-Verlag, Berlin, 1990.
2. G.K. Owens, M. S. Kumar, B.R. Wamhoff. Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol Rev 84(3): 767-801. 2004
3. Lacolley P(1), Regnault V, Nicoletti A, Li Z, Michel JB. The vascular smooth muscle cell in arterial pathology: a cell that can take on multiple roles. Cardiovasc Res. 2012
4. Herbert SP(1), Stainier DY. Molecular control of endothelial cell behaviour during blood vessel
morphogenesis. Nat Rev Mol Cell Biol. 2011
5. Zhang et al. Blood flow and stem cells in vascular disease. Cardiovasc Res 2013
6. Gomez et al. Epigenetic Control of Smooth Muscle Cell Identity and Lineage Memory. Arterioscler Thromb Vasc Biol 2015
Number of students 10 - 22
Selection of students Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date)
More information This is a fulltime course and will be held from Monday May 15th to Friday May 19th 2017. The lectures will be primarily held at the CMM lecture hall in Karolinska University Hospital Solna.
Additional course leader
Latest course evaluation Course evaluation report
Course responsible Joy Roy
Institutionen för molekylär medicin och kirurgi

Joy.Roy@ki.se
Contact person Joy Roy
Institutionen för molekylär medicin och kirurgi

Joy.Roy@ki.se


 Ljubica Matic
Institutionen för molekylär medicin och kirurgi

ljubica.matic@ki.se