Course catalogue doctoral education - VT20

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Title The epigenome: a platform for the integration of metabolic and signaling pathways in development and on the path to diseases
Course number 2942
Programme Cellbiologi och genetik
Language English
Credits 1.5
Date 2017-01-16 -- 2017-01-20
Responsible KI department Institutionen för mikrobiologi, tumör- och cellbiologi
Specific entry requirements
Purpose of the course To increase the understanding of the interplay between epigenetic regulation, signalling and metabolic pathways in complex human diseases.
Intended learning outcomes Following the completion of the course the students will be able to describe and discuss the basic principles of epigenetic regulation and the role of chromatin in the maintenance of cellular phenotypes. Moreover, the students will learn how various signaling and metabolic pathways alter chromatin states during ageing and in human diseases, such as cancer, diabetes and psychiatric disorders. The students will also be able to design experiments for studying chromatin marks and to critically evaluate results obtained with these techniques.
Contents of the course The course covers the molecular mechanisms of epigenetic regulation and how chromatin based processes are linked to human diseases. Particular attention will be paid to the crosstalk between chromatin marks and cellular signaling pathways as well as metabolism. Furthermore, we will discuss the regulation of these processes during the circadian cycle and their deregulation in cancer, diabetes mellitus and psychiatric diseases.
Teaching and learning activities The learning activities used in the course include lectures, research seminars, group discussions, problem-based learning and research article presentations by the students. Every student will present a recent publication in the form of a journal club. Students will also be encouraged to actively participate in the course. There will be substantial time for discussions after the lectures and research seminars.
Compulsory elements The lectures, seminars, group discussions and journal club presentations are compulsory.
Examination Examination is based on the journal club presentation (summative assessment) and on active participation in discussions during the course (formative assessment). Every student will be at one occasion presenting a pre-selected article and at another occasion will be the opponent for the presentation of a fellow student. The student's performance at these two occasions will be the basis for the final assessment.
Literature and other teaching material Recent articles in the field.
Number of students 10 - 18
Selection of students Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date)
More information The course takes place at MTC, KI.
Additional course leader The course director is Anita Göndör Institutionen för mikrobiologi, tumör- och cellbiologi 08 524 862 03 anita.gondor@ki.se
Latest course evaluation Not available
Course responsible Matti Nikkola
Institutionen för cell- och molekylärbiologi

Matti.Nikkola@ki.se
Contact person Anita Göndör
Institutionen för onkologi-patologi
08 524 862 03
anita.gondor@ki.se