Course catalogue doctoral education - VT18

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Title The developing brain
Course number 2780
Program Neurovetenskap
Language English
Credits 1.5
Date 2016-08-29 -- 2016-09-02
Responsible KI department Institutionen för medicinsk biokemi och biofysik
Specific entry requirements
Learning outcomes By the end of the course the student shall be able to describe the major steps contributing to the development of the brain and transfer new knowledge acquired in the course into their specific projects or fields of research. The student should be able to explain basic principles behind neural development such as patterning, specification from neural stem cells to neurons and oligodendrocytes, migration, neurite outgrowth, axon path-finding, synapse formation, neuro-glia interactions, the role of neuronal activity, and regeneration final circuit integration. Describe key concepts such as epigenetic states, cell potency and fate-restriction, transcriptional programs. To apply and understand the readout of modern methods of probing developmental questions including inducible genetic fate-mapping, manipulation and tissue culture systems in different animal model systems as well as transcriptomic analysis.
Contents of the course The course will cover the main developmental steps for creating the mature circuits in the brain, including the patterning of the neural plate and thus the origin of cell types, the interplay between intrinsic and extrinsic factors, neuro-glia interactions and the role of network activity in shaping the final circuits. Different molecular and tracing technologies, and model organisms will be covered. An important aspect of the course regards molecular technologies for labelling, transcriptional analysis and genetic manipulation of defined neural populations. Connections between aberrant developmental processes and neurological disorders will be covered.
Teaching and learning activities Lectures by invited experts, group work, seminar presentations.
Compulsory elements All lectures and the seminar presentation (examination) are compulsory. Students who cannot attend will be given the opportunity to perform an individual seminar presentation and take part in an individual exam.
Examination The students should demonstrate their knowledge about the items stated as individual learning outcomes during interaction with invited experts, group work and presentations. They should demonstrate that they can critically evaluate original research papers on these topics in a seminar presentation and in discussions.
Literature and other teaching material Original research articles and review articles provided by the course organisers.
Number of students 10 - 30
Selection of students Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date)
More information The course is a full time course (09.00-16.00) and will be given at the Department of Neuroscience (Room Tellus, Scheeles väg 1, 5th floor). The course will offer opportunity to interact with leading invited international neuroscientist. This year will also contain enteric nervous system development.
Additional course leader Ulrika Marklund (MBB) Goncalo Castelo-Branco (MBB) Jens Hjerling-Leffler (MBB)
Earlier evaluation of the course Evaluation report
Course responsible Jens Hjerling-Leffler
Institutionen för medicinsk biokemi och biofysik

jens.hjerling-leffler@ki.se
Contact person Goncalo Castelo-Branco
Institutionen för medicinsk biokemi och biofysik

Goncalo.Castelo-Branco@ki.se