Course catalogue doctoral education - VT18

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Title Regulatory RNAs in Development, Disease and Evolution
Course number 2865
Program 1-Ingår i flera program
Language English
Credits 2.0
Date 2015-10-07 -- 2015-10-16
Responsible KI department Institutionen för medicinsk biokemi och biofysik
Specific entry requirements -
Learning outcomes After completing the course, the students should be able to:

- describe the different kinds of regulatory RNAs in development, disease and evolution, and their mechanism of action
- describe and critically evaluate the application of emerging experimental strategies for the study of regulatory RNAs
- transfer the knowledge acquired in the course into their specific projects and fields of research.
Contents of the course The course will cover key concepts concerning regulatory RNAs and their mechanisms of action. The following themes will be covered: Different kinds of regulatory (non-coding) RNAs in eukaryotes, regulatory RNAs in development and disease, regulatory RNAs in virus and bacteria, evolution of regulatory RNAs, RNA dynamics and RNA methodologies (bioinformatics and emerging experimental strategies).
Teaching and learning activities The learning activities include lectures, seminars, group discussions and presentations. The students will present themselves with short chalk talks on the first day. They will be divided into groups and will have several sessions designated for groups discussions and brainstorming to transfer and apply the new knowledge acquired during the course into their specific projects and fields of research. Each group will present and discuss their conclusions from these discussions to all the other students and course directors.
Compulsory elements Lectures, seminars, group discussions and presentations are mandatory. Compensation in case of absence according to the instructions of the course director.
Examination Examination according to the intended learning outcomes of the course will take place in form of a presentation, where the course participants will discuss the transfer of the knowledge acquired during the course into their specific projects and fields of research. Each course participant will be assessed individually.
Literature and other teaching material Scientific articles according to the recommendations from the lecturers and course organisers.
Number of students 15 - 30
Selection of students The selection is based on relevance of the course content for their doctoral project and the personal motivation included in the course application.
More information The course is full time. Most of the course lectures will be given at the main seminar room at the Scheele building, Department of Medical Biochemistry and Biophysics (A3 311). The students will participate in a Karolinska Institutet conference on Regulatory RNAs and Chromatin at the Nobel Forum, October 16th 2015, with the following speakers confirmed: Leonie Ringrose, Institute of Molecular Biotechnology, Vienna, Austria, Johan Jakobsson, Lund University, John Rinn, Harvard University, USA, Raffaella Santoro, University of Zurich, Switzerland, Marcel Dinger, Garvan Institute of Medical Research, Sidney, Australia and Tony Kouzarides, University of Cambridge, United Kingdom. The course is jointly organized by Karolinska Institutet and Uppsala University and co-funded by the doctoral programme in Regenerative medicine, doctoral programme in Cell Biology and Genetics (see and DBRM (
This course has previously been given as a one week course (1,5 hp), course number 2698.
Additional course leader The course directors are: Gonçalo Castelo-Branco, Karolinska Institutet (, Andrea Hinas, Uppsala University ( and Paulo Amaral, University of Cambridge, United Kingdom (
Earlier evaluation of the course Evaluation report
Course responsible Goncalo Castelo-Branco
Institutionen för medicinsk biokemi och biofysik
Contact person -