Course catalogue doctoral education - HT19

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Title How to conduct systematic reviews and meta-analyses
Course number 2790
Programme Folkhälsovetenskap
Language English
Credits 3.0
Date 2015-10-19 -- 2015-11-04
Responsible KI department Institutionen för molekylär medicin och kirurgi
Specific entry requirements
Intended learning outcomes After completion of the course the students should be able to: 1) Independently plan and produce a study protocol to perform a systematic review and meta-analysis, including a detailed description of the selection of the eligible studies and statistical methodology. 2) Critically reflect on other students individual project work in a scientifically constructive way. 3) Interpret and critically evaluate scientific studies relevant to the course content.
Contents of the course The course is designed for PhD students, in particular those who are at an early stage of their research education, and those with an interest in conducting systematic reviews and meta-analysis. The content of the course is as follows: 1) Basic terms in systematic reviews and meta-analyses, 2) How to write a study protocol for a systematic review, 3) How to perform a systematic literature search, 4) Data-extraction and quality assessment of included studies, 5) Statistical methods used in meta-analyses and interpretation, 6) Problems and limitations of systematic reviews and meta-analysis, 7) Examination and course evaluation. Throughout the course, the students will work on an individual project and will have to peer-review the project of another student. Further, students will critically review and discuss relevant scientific articles.
Teaching and learning activities Lectures, seminars, individual article review, group discussions, practical sessions (one on systematic literature search, one on statistical methods) and homework tasks will be used. The course focuses on active learning, i.e. putting knowledge into practice and critically reflecting upon the knowledge, rather than memorising facts. Therefore, much of the focus of the course is on the individual project where students are required to develop a full study protocol including several important aspects covered in the lectures, article reviews and group discussions. Students will also peer-review each other¿s projects and this will form the basis for the final examination seminar.
Compulsory elements Compulsory attendance includes the scheduled lectures and seminars. Absence will need to be replaced by individual assignments following discussion with the course co-ordinator, e.g. article reviews, with written or oral follow-up.
Examination To pass the course the student must actively participate in the course and pass the examinations: 1) Individual project work: To develop a written comprehensive yet concise study protocol including several important aspects as discussed during the course; 2) Peer-review of other students¿ projects followed by an oral presentation of their own project and opposition of other students projects during the group examination; 3) Critically review scientific articles relevant to the course content and participate actively in the seminars.
Literature and other teaching material Course literature (Mandatory) 1. Berlin JA, Golub RM. Meta-analysis as evidence: Building a better pyramid. JAMA 2014:312(6):603-605. PubMed PMID: 25117128 Before course starts 2. Systematic Reviews in Health Care: Meta-analysis in context (2nd edition, 2008, Egger et al - First edition was from Charmers and Altman 1995, BMJ publishing group): ( (free online as e-book via KI library) Chapter 1 (read before course starts), 3 and 9. 3. Introduction to meta-analysis. (2009, Borenstein et al) (free online as e-book via KI library) ( Part 3, 4 and 9. 4. Moher D, Liberati A, Tetzlaff J, Altman DG; PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol. 2009 Oct;62(10):1006-12. doi: 10.1016/j.jclinepi.2009.06.005. Epub 2009 Jul 23. PubMed PMID: 19631508. 5. Sanderson S, Tatt ID, Higgins JP. Tools for assessing quality and susceptibility to bias in observational studies in epidemiology: a systematic review and annotated bibliography. Int J Epidemiol. 2007 Jun;36(3):666-76. Epub 2007 Apr 30. Review. PubMed PMID: 17470488. To read for literature seminars: 1. Malik VS, Pan A, Willett WC, Hu FB. Sugar-sweetened beverages and weight gain in children and adults: a systematic review and meta-analysis. Am J Clin Nutr. 2013 Oct;98(4):1084-102. doi: 10.3945/ajcn.113.058362. Epub 2013 Aug 21. Review. PubMed PMID: 23966427; PubMed Central PMCID: PMC3778861. 2. De Bruijn KM, Arends LR, Hansen BE, Leeflang S, Ruiter R, van Eijck CH. Systematic review and meta-analysis of the association between diabetes mellitus and incidence and mortality in breast and colorectal cancer. Br J Surg. 2013 Oct;100(11):1421-9. doi: 10.1002/bjs.9229. Review. PubMed PMID: 24037561. Suggested reading (optional) 1. Cochrane handbook (free online) ( 2. Systematic Reviews. CRD¿s guidance for undertaking reviews in health care (2009). Centre for Reviews and Dissemination, University of York. ISBN 978-1-900640-47-3. (free to download online): discussion of different types of systematic reviews (clinical tests, public health interventions)
Number of students 20 - 25
Selection of students Selection will be based on 1) Date of registration as a PhD student 2) suitability of PhD project 3) The motivation to attend the course.
More information
Additional course leader
Earlier evaluation of the course Evaluation report
Course responsible Nele Brusselaers
Institutionen för mikrobiologi, tumör- och cellbiologi

CTMR - Nobelsvag 16 - KISolna

Contact person Kalle Mälberg
Institutionen för molekylär medicin och kirurgi