Kurskatalog forskarutbildning - VT19

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Titel Applied Psychoneuroimmunology
Kursnummer 2741
Program Allergi, immunologi och inflammation (Aii)
Språk Engelska
Antal högskolepoäng 6.0
Datum 2014-01-27 -- 2014-05-30
Kursansvarig institution Institutionen för klinisk neurovetenskap
Särskild behörighet
Kursens lärandemål Knowledge and understanding
- Describe the essential concepts in psychoneuroimmunology - the basic mechanisms by which the nervous, the endocrine and the immune system communicate, and why behavior is relevant in this communication.
- Understand possibilities and limitations of research methods in psychoneuroimmunology
Skills and ability
- Independently be able to explain core research findings regarding brain-immune interactions.
Making judgment and approach
- Be able to judge the relevance of a pscyhoneuroimmunological perspective in own research
Kursens innehåll The main content of the course is an overview of present knowledge in psychoneuroimmunology: the functional relations between the nervous system, the endocrine system, the immune system and behavior. The course aims at a deepened understanding of the communication between the nervous system, the endocrine and the immune system, boths in terms of involved mechanisms and the functional concequences at different observational levels in a given disease process.
Arbetsformer The course is given part time/day time and is organised around litterature studies in two phases. The first phase consists of reading and discussion of litterature (ca 400 pages) that is mutual for all participants. The second part consists of reading and discussion of litterature chosen to reflect neuroimmunological perspectives specific to each student's specific research area (ca 350 pages). The litterature is discussed in seminars. The doctoral student has access to supervision throughout the course.
Obligatoriska moment Presence at the seminars is recommended but not mandatory.
Examination The examinations will be done as a written contribution from each participant. The written part should be constructed in the form of an introductory text to a manuscript. Preferably, this should introduce a research question in the research plan of the PhD student.
Kurslitteratur och övriga läromedel 1. General part: Exerpts from Psychoneuroimmunology (2006), fourth edition, Ader, R. (ed.), (Vol. 1). San Diego, California: Academic Press. Part I: Nervous system effects on immunity (pp. 39-251). Part II: Neuroendocrine effects on immunity (pp. 267-429). Ca 370 pages. Steinman, L. (2004). Elaborate interactions between the immune and nervous systems. Nat Immunol, 5(6), 575-581. Tracey, K. J. (2002). The inflammatory reflex. Nature, 420(6917), 853-859. Bryant, P. A., Trinder, J., & Curtis, N. (2004). Sick and tired: Does sleep have a vital role in the immune system? Nat Rev Immunol, 4(6), 457-467. 2. Specific part: Scientific articles selected by the course leaders and proposed by each student (ca 350 pages/student), may include a selection of these: Bamberger, C. M., H. M. Schulte, et al. (1996). "Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids." Endocrine Reviews. 17(3): 245-61. Bierhaus, A., Wolf, J., Andrassy, M., Rohleder, N., Humpert, P. M., Petrov, D., et al. (2003). A mechanism converting psychosocial stress into mononuclear cell activation. Proc Natl Acad Sci U S A, 100(4), 1920-1925. Buske-Kirschbaum, A. and D. H. Hellhammer (2003). "Endocrine and immune responses to stress in chronic inflammatory skin disorders." Annals of the New York Academy of Sciences. 992:231-40, 2003 May. Buske-Kirschbaum, A., S. Jobst, et al. (1998). "Altered reactivity of the hypothalamus-pituitary-adrenal axis in patients with atopic dermatitis: pathologic factor or symptom?" Annals of the New York Academy of Sciences. 840: 747-54. Buske-Kirschbaum, A., K. von Auer, et al. (2003). "Blunted cortisol responses to psychosocial stress in asthmatic children: a general feature of atopic disease?" Psychosomatic Medicine 65(5): 806-10. Busse, W. W., & Rosenwasser, L. J. (2003). Mechanisms of asthma. J Allergy Clin Immunol, 111(3 Suppl), S799-804. Chen, X., Murakami, T., Oppenheim, J. J., & Howard, O. M. (2004). Differential response of murine CD4+CD25+ and CD4+CD25- T cells to dexamethasone-induced cell death. Eur J Immunol, 34(3), 859-869. Chikanza, I. C., P. Petrou, et al. (1992). "Defective hypothalamic response to immune and inflammatory stimuli in patients with rheumatoid arthritis.[comment]." Arthritis & Rheumatism. 35(11): 1281-8. Chrousos, G. P. (1995). "The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation." N Engl J Med(332): 1351-1362. Chrousos, G. P., Gold, P.W. (1992). "The concepts of stress and stress system disorders: overview of physiological and behavioral homeostasis." JAMA(267): 1244-1252. Curotto de Lafaille, M. A., & Lafaille, J. J. (2002). CD4(+) regulatory T cells in autoimmunity and allergy. Curr Opin Immunol, 14(6), 771-778. DeRijk, R. H., J. Petrides, et al. (1996). "Changes in corticosteroid sensitivity of peripheral blood lymphocytes after strenuous exercise in humans." J Clin Endocrinol Metab 81(1): 228-35. Dhabhar, F. S. (2002). "Stress-induced augmentation of immune function-The role of stress hormones, leukocyte trafficking, and cytokines." Brain, Behavior, & Immunity 16(6): 785-98. Ebrecht, M., A. Buske-Kirschbaum, et al. (2000). "Tissue specificity of glucocorticoid sensitivity in healthy adults." J Clin Endocrinol Metab 85(10): 3733-9. Grossi G, Perski A, Evengård B, Blomkvist V, Orth-Gomér K.Physiological correlates of burnout among women. J Psychosom Res. 2003;55:309-16. Grota, L. J., T. Bienen, et al. (1997). "Corticosterone responses of adult Lewis and Fischer rats." Journal of Neuroimmunology. 74(1-2): 95-101. Hallman T.(2003). Gender perspective on psychological risc factors osv. Dissertation. Hertting A.(2003). The health care sector: A challenging or draining work environment. Dissertation. Knutsson, U. (2000). Individual glucocorticoid sensitivity in the human. Department of clinical sciences, division of ENT diseases. Stockholm, Karolinska Institutet, Huddinge university hospital: 38. Knutsson, U., Werner, S., Stierna, P., Wikström, A-C. (subm. 2003). "The short low-dose ACTH, alone or in combination with the low-dose DST reveals interindividual differences in HPA axis regulation." J. Endocrinol. Liu, L. Y., C. L. Coe, et al. (2002). "School Examinations Enhance Airway Inflammation to Antigen Challenge." Am. J. Respir. Crit. Care Med. 165 http://ajrccm.atsjournals.org/cgi/content/abstract/165/8/1062(8): 1062-1067. Maier F. S., Watkins R. L. (1998) Cytokines for psychologists: Implications of Bidirectional Immune-to-Brain Communication for Understanding Behaviour, Mood, And Cognition. Psychological Review, Vol. 105, No 1, 83-107. Rohleder, N., B. M. Kudielka, et al. (2002). "Age and sex steroid-related changes in glucocorticoid sensitivity of pro-inflammatory cytokine production after psychosocial stress." Journal of Neuroimmunology. 126(1-2): 69-77. Sandberg, S., Paton, J. Y., McCann, D. C., McGuinness, D., Hillary, C. R., Oja, H. (2000). "The role of acute and cronic stress in asthma attacks in children." Lancet 356: 982-87. Sapolsky, R. M., L. M. Romero, et al. (2000). "How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions." Endocr Rev 21(1): 55-89. Wei R, Listwak SJ, Sternberg EM. Lewis hypothalamic cells constitutively and upon stimulation express higher levels of mRNA for pro-inflammatory cytokines and related molecules: comparison with inflammatory resistant Fischer rat hypothalamic cells. J NeuroImmunol 2003; 135: 10-28 Wirtz, P. H., K. R. von, et al. (2003). "Reduced glucocorticoid sensitivity of monocyte interleukin-6 production in male industrial employees who are vitally exhausted." Psychosomatic Medicine 65(4): 672-8. Lekander, M. (2001). Anticipatory stress influences the immune system. Evidence from chemotherapy related blood samples in cancer patients. Scandinavian Journal of Behavior Therapy, 30(1), 33-39. Lekander, M., Fredrikson, M., & Wik, G. (2000). Neuroimmune relations in patients with fibromyalgia: a positron emission tomography study. Neurosci Lett, 282(3), 193-196. Lekander, M., Gustavsson, M., Elofsson, S., Neve, I.-M., & Unden, A. L. (2004). Perception of subjective health is associated with levels of circulating cytokines in primary health care. Psychosomatic Medicine, in press. Alleva, E., Petruzzi, S., Cirulli, F., & Aloe, L. (1996). NGF regulatory role in stress and coping of rodents and humans. Pharmacol Biochem Behav, 54(1), 65-72. Olgart, C., de Blay, F., Duvernelle, C., Oster, J.-P., Pauli, G., & Frossard, N. (2000). Elevated levels of nerve growth factor (NGF) in bronchial lavage from mild asthmatics; localization of the sources of NGF in human bronchi. Submitted. Olgart Hoglund, C., de Blay, F., Oster, J. P., Duvernelle, C., Kassel, O., Pauli, G., et al. (2002). Nerve growth factor levels and localisation in human asthmatic bronchi. Eur Respir J, 20(5), 1110-1116. Sanico, A. M., Koliatsos, V. E., Stanisz, A. M., Bienenstock, J., & Togias, A. (1999). Neural hyperresponsiveness and nerve growth factor in allergic rhinitis. International Archives of Allergy & Immunology, 118(2-4), 154-158. Sanico, A. M., Stanisz, A. M., Gleeson, T. D., Bora, S., Proud, D., Bienenstock, J., et al. (2000). Nerve growth factor expression and release in allergic inflammatory disease of the upper airways. Am J Respir Crit Care Med, 161(5), 1631-1635. Shevach, E. M. (2002). CD4+ CD25+ suppressor T cells: more questions than answers. Nat Rev Immunol, 2(6), 389-400. Takeno, S., Hirakawa, K., Ueda, T., Furukido, K., Osada, R., & Yajin, K. (2002). Nuclear factor-kappa B activation in the nasal polyp epithelium: relationship to local cytokine gene expression. Laryngoscope, 112(1), 53-58. Scully, J. L., & Otten, U. (1995). NGF: Not just for neurons. Cell Biology International, 19(5), 459-469. Craig, A. D. (2002). "How do you feel? Interoception: the sense of the physiological condition of the body." Nat Rev Neurosci 3(8): 655-666. Mayer, E. A., B. D. Naliboff, et al. (2006). "Neuroimaging of the brain-gut axis: from basic understanding to treatment of functional GI disorders." Gastroenterology 131(6): 1925-1942.
Antal studenter 3 - 25
Urval av studenter Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date)
Övrig information The basis for this part time course are self-studies of assigned litterature with four seminars for discussions with invited discussants, course leaders and students.
Ytterligare kursledare Mats Lekander, Department of clinical neuroscience. The course is given in collaboration with the Stress Research Institute, Stockholm University and Stockholm Stress Center
Tidigare omdöme av kursen Not available
Kursansvarig Anna Nixon Andreasson
Institutionen för klinisk neurovetenskap

Anna.Andreasson@ki.se
Kontaktpersoner Anna Nixon Andreasson
Institutionen för klinisk neurovetenskap

Anna.Andreasson@ki.se