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Title Regulatory RNAs in Development, Disease and Evolution
Course number 2698
Programme X- Används inte längre - Regenerativ medicin
Language English
Credits 1.5
Date 2013-09-30 -- 2013-10-08
Responsible KI department Institutionen för medicinsk biokemi och biofysik
Specific entry requirements -
Intended learning outcomes After completing the course, the students should be able to describe the different kinds of regulatory RNAs in development, disease and evolution, and their mechanism of action, describe and critically evaluate the application of emerging experimental strategies for the study of regulatory RNAs and transfer the knowledge acquired in the course into their specific projects and fields of research.
Contents of the course The course will cover key concepts in regulatory RNAs. The following themes will be covered: Different kinds of regulatory (non-coding) RNAs in eukaryotes, regulatory RNAs in development and disease, regulatory RNAs in virus and bacteria, evolution of regulatory RNAs, RNA transport and RNA methodologies (bioinformatics and emerging experimental strategies).

The students will present themselves with short chalk talks on the first day. They will be divided into groups and will have 3 hours designated for groups discussions and brainstorming to transfer and apply the new knowledge acquired during the course into their specific projects and fields of research. Each group will present and discuss their conclusions from these discussions to all the other students and course directors.

The students will attend an international mini-symposium on Regulatory RNAs with international speakers.
Teaching and learning activities The learning activities include lectures, seminars in the mini-symposium, group discussions and presentations.
Compulsory elements Lectures, seminars in the mini-symposium, group discussions and presentations are mandatory. Compensation according to the instructions of the course director.
Examination Examination will take place in form of a presentation, where the course participants will discuss the transfer of the knowledge acquired during the course into their specific projects and fields of research. Each course participant will be assessed individually. Each course participant will be assessed individually.
Literature and other teaching material Scientific articles according to the recommendations from the lecturers and course organisers.
Number of students 15 - 20
Selection of students The selection is based on relevance of the course content for their doctoral project and the personal motivation included in the course application.
More information The course is full time. Most of the course lectures will be given at the main seminar room at the Scheele building, Department of Medical Biochemistry and Biophysics (A3 311). During October 8, the students participate in an international symposium on Regulatory RNAs organized at the Nobel Forum, with Professors John Mattick, Erik Miska, Antonio Giraldez and Howard Chang. The course is jointly organized by Karolinska Institutet, Uppsala University and co-funded by the doctoral course program in Regenerative medicine and DBRM (www.dbrm.se).
Additional course leader The course directors are: Gonçalo Castelo-Branco, Karolinska Institutet (Goncalo.Castelo-Branco@ki.se), Andrea Hinas, Uppsala University (andrea.hinas@imbim.uu.se) and Paulo Amaral, University of Cambridge, United Kingdom (p.amaral@gurdon.cam.ac.uk).
Latest course evaluation Not available
Course responsible Goncalo Castelo-Branco
Institutionen för medicinsk biokemi och biofysik

Goncalo.Castelo-Branco@ki.se
Contact person -