Course catalogue doctoral education - HT19

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Title Genetic Epidemiology
Course number 2228
Programme Epidemiologi
Language English
Credits 1.5
Date 2013-04-15 -- 2013-04-26
Responsible KI department Institutionen för medicinsk epidemiologi och biostatistik
Specific entry requirements Knowledge in epidemiology and biostatistics equivalent to ""Epidemiology I: Introduction to epidemiology"" (course 1577), ""Epidemiology II: Design of epidemiological studies"" (course 1622), ""Biostatistics I: Introduction for epidemiologists"" (course 1579) and ""Biostatistics II: Logistic regression for epidemiologists"" (course 1513).
Intended learning outcomes After successfully completing this course you as a student are expected to be able to:
-Describe the basic organization of the human genome and the central dogma of eukaryote genetics.
-Relate the concepts of meiosis, recombination, linkage and linkage disequilibrium to each other.
-Draw conclusions about genetic influences from trait distributions in families and estimate the relative degree of genetic influences from twin correlation data.
-Describe the principal differences between candidate gene approach and genome-wide association studies.
-Explain the concept of genome-wide significance levels and the role of replication for genetic association studies.
-Use internet databases to find positions of genetic markers and to identify suitable tag markers for candidate genes.
Contents of the course The course is about concepts and methods used in studies of genetic variation influencing disease and other phenotypes. It will cover basic genetic mechanisms and Mendelian inheritance, complex and quantitative trait inheritance, gene-discovery strategies with advantages and disadvantages. Primary focus is genetic association studies with study design and interpretation of results.
Teaching and learning activities Lectures, group work, computer demonstration and home task.
Compulsory elements Only the examination is compulsory.
Examination To pass the course, the student has to show that the learning outcomes have been achieved. Active participation in group work and group task assessments is required. One assessment of the learning outcomes consists of a written home exam, which students have one week to complete after the course end. Students who do not obtain a passing grade at the first two examinations will be given top priority for admission the next time the course is offered
Literature and other teaching material Recommended reading: Compendium covering basic genetic concepts will be distributed before the course. Scientific articles and hand-outs distributed during the course.
Number of students 12 - 25
Selection of students Eligible doctoral students will be prioritized according to 1) the relevance of the course content for their research, 2) the stated motivation for attending. To be considered, submit a completed application, give all info. requested, incl. description of current research and a motivation for attending, and an account of previous courses.
More information The course is given April 15, 17, 19, 24 and 26 at Karolinska Institutet Campus Solna. The course is extended over two weeks (but still 5 course days) to promote reflection and active learning.
Additional course leader
Earlier evaluation of the course Not available
Course responsible Patrik Magnusson
Institutionen för medicinsk epidemiologi och biostatistik
0852482353
Patrik.Magnusson@ki.se
Contact person Marie Beckeman
Institutionen för medicinsk epidemiologi och biostatistik
+46 8 524 82471
Marie.Beckeman@ki.se