Course catalogue doctoral education - VT24
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| Title | Multifactorial immune mediated diseases - etiology and pathogenesis |
|---|---|
| Course number | 2532 |
| Programme | Allergi, immunologi och inflammation (Aii) |
| Language | English |
| Credits | 1.5 |
| Date | 2011-10-03 -- 2011-10-14 | Responsible KI department | Institutionen för medicinsk biokemi och biofysik |
| Specific entry requirements | No |
| Intended learning outcomes | After completion of the course the students should be able to explain the term multifactorial immune mediated diseases (e.g. allergic, autoimmune, and inflammatory) and discuss basic clinical characteristics and disease mechanisms. They should be able to discuss the role of environment and genes in the etiology of such diseases, and in particular that the diseases are genetically complex. The students should also be able to describe some genetic strategies aimed at identifying risk genes. They should be able to explain how identification of risk genes can give insight into disease pathways, and discuss how such knowledge may enable disease prevention and therapy. |
| Contents of the course | The course includes an overview on chronic immune mediated multifactorial diseases and the challenge they represent to medicine. It covers topics such as epidemiology, clinical characteristics, suggested or known disease mechanisms and genetics including experimental animal models available to study such multifactorial and polygenetic diseases and bioinformatics tools available to analyze results. Key concepts and techniques within each topic will be introduced. |
| Teaching and learning activities | Each day, the course combines a set of morning overview lectures on clinical diseases followed by a lecture on pre-clinical experimental models and in the afternoon a seminar with a task to solve, at either group or individual level. The tasks generally consists of ""scientific projects"" that are pursued by combining knowledge acquired during morning lectures with information that is either given and/or collected in databases. |
| Compulsory elements | All lectures, seminars and group- or individual- tasks are compulsory. Compensation for absence can be discussed with the course director. |
| Examination | Examination is based on interactive engagement during daily discussions in the afternoon sessions for the first 4 days. During last day, participating students will be divided into groups. Each student should prepare, present and discuss questions (minimum: 3-5) based on earlier presentations and published papers given during the course to their group members (peer-learning), which will be facilitated by three senior scientists. |
| Literature and other teaching material | Course litterature consists of lecture handouts and selected scientific publications given during the course. In addition, the following books are recommended but not compulsory: Human Molecular Genetics (2003), by Strachan and Read. Immunobiology, 6 th edition, Travers et al. |
| Number of students | 12 - 16 |
| Selection of students | Selection will be based on date for registration as a doctoral student. |
| More information | This course is only for 5 days spread over during two weeks (3rd Oct to 14th Oct) time to accommodate timings of different scientists/professors. It will be conducted in MBB, Scheelesvag 2, KI (Solna). This course contains lectures/seminars involving both clinical and pre-clinical aspects of several autoimmune diseases. Genetic and immunological view of disease pathogenesis of autoimmune diseases will be discussed extensively. Most importantly, animal models available to these diseases will be presented along with practical aspects of establishing such animal models in your own lab for your studies. Bioinformatics tools available to explore genetics basis of these diseases will also be discussed. |
| Additional course leader | |
| Latest course evaluation | Not available |
| Course responsible |
Nandakumar Kutty Selva Institutionen för medicinsk biokemi och biofysik 08-52487715 Nandakumar.Kutty-Selva@ki.se Scheelesvag 2, B2, plan 4 17177 Stockholm |
| Contact person |
Magdalena Janzi Ej satt Magdalena.Janzi@ki.se |
